Bratelj, Denis; Stalder, Susanne; Capone, Crescenzo; Jaszczuk, Phillip; Dragalina, Cristian; Pötzel, Tobias; Gebhard, Catherine; Fiechter, Michael (2023). Spinal cord tethering and syringomyelia after trauma: impact of age and surgical outcome. Scientific reports, 13(1), p. 11442. Springer Nature 10.1038/s41598-023-38565-0
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Spinal_cord_tethering_and_syringomyelia_after_trauma_impact_of_age_and_surgical_outcome.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Posttraumatic spinal cord tethering and syringomyelia frequently lead to progressive neurological loss. Although several studies demonstrated favourable outcome following spinal cord detethering with/without shunting, additional research is required as no clear consensus exists over the ideal treatment strategy and knowledge about prognostic demographic determinants is currently limited. In this investigation, we retrospectively investigated 67 patients (56 men, 11 women) who were surgically treated and followed for symptomatic spinal cord tethering and syringomyelia from 2012 to 2022 at our center. Age (B-coefficient 0.396) and severity of trauma to the spinal cord (B-coefficient - 0.462) have been identified as independent predictors for the rate of development of symptomatic spinal cord tethering and syringomyelia (p < 0.001). Following untethering surgery including expansion duraplasty with/without shunting, 65.9% of patients demonstrated an improvement of neurological loss (p < 0.001) whereas 50.0% of patients displayed amelioration of spasticity and/or neuropathic pain (p < 0.001). Conclusively, active screening for symptomatic spinal cord tethering and syringomyelia, particularly in younger patients with severe spinal trauma, is crucial as surgical untethering with/without shunting is able to achieve favourable clinical outcomes. This knowledge may enable clinicians to tailor treatment strategies in spinal cord injury patients suffering from progressive neurological loss towards a more optimal and personalized patient care.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Gebhard, Cathérine Simone |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Tanja Gilgen |
Date Deposited: |
29 Dec 2023 10:43 |
Last Modified: |
29 Dec 2023 10:43 |
Publisher DOI: |
10.1038/s41598-023-38565-0 |
PubMed ID: |
37454226 |
BORIS DOI: |
10.48350/190940 |
URI: |
https://boris.unibe.ch/id/eprint/190940 |
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