Galbusera, Riccardo; Bahn, Erik; Weigel, Matthias; Cagol, Alessandro; Lu, Po-Jui; Schaedelin, Sabine A; Franz, Jonas; Barakovic, Muhamed; Rahmanzadeh, Reza; Dechent, Peter; Nair, Govind; Brück, Wolfgang; Kuhle, Jens; Kappos, Ludwig; Stadelmann, Christine; Granziera, Cristina (2024). Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis. Neurology, 102(3), e207966. American Academy of Neurology 10.1212/WNL.0000000000207966
Full text not available from this repository. (Request a copy)BACKGROUND AND OBJECTIVES
A subgroup of patients with multiple sclerosis (MS) presents focal paramagnetic rims at the border between cortex and white matter (juxtacortical paramagnetic rims [JPRs]). We investigated the presence of this finding in our in vivo MS cohort and explored its potential clinical relevance. Moreover, we exploited postmortem MRI of fixed whole MS brains to (1) detect those rims and (2) investigate their histologic correlation.
METHODS
Quantitative susceptibility mapping (QSM) and magnetization-prepared 2 rapid acquisition gradient-echo (MP2RAGE) images at 3T-MRI of 165 patients with MS from the in vivo cohort were screened for JPRs and the presence of cortical lesions. Five postmortem brains from patients with MS were imaged with 3T-MRI to obtain QSM and MP2RAGE sequences. Tissue blocks containing JPRs were excised and paraffin-embedded slices stained by immunohistochemistry for myelin basic protein (for myelin) and anti-CR3/43 (for major histocompatibility complex II-positive microglia/macrophages). DAB-Turnbull stain was performed to detect iron.
RESULTS
JPRs are present in approximately 10% of in vivo patients and are associated with increased cortical lesion load. One of the 5 postmortem brains showed JPRs. Histologically, JPRs correspond to an accumulation of activated iron-laden phagocytes and are associated with demyelination of the whole overlying cortical ribbon.
DISCUSSION
JPRs are a novel potential MRI biomarker of focal cortical demyelination, which seems related to global cortical pathology and might be useful for diagnostic and stratification purposes in a clinical setting.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Rahmanzadeh, Reza |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1526-632X |
Publisher: |
American Academy of Neurology |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Jan 2024 08:46 |
Last Modified: |
14 Jan 2024 02:43 |
Publisher DOI: |
10.1212/WNL.0000000000207966 |
PubMed ID: |
38165297 |
URI: |
https://boris.unibe.ch/id/eprint/191060 |
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