Diagnostics and therapy of paediatric patients with febrile neutropenia

Koenig, Christa; Lehrnbecher, Thomas (2023). Diagnostics and therapy of paediatric patients with febrile neutropenia. EJC Paediatric Oncology, 2, p. 100116. Elsevier 10.1016/j.ejcped.2023.100116

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Febrile neutropenia is a common infectious complication in children and adolescents receiving chemotherapy for cancer, requiring immediate hospitalisation and empirical antibacterial therapy. The risk for a severe infection increases with lower neutrophil counts, but other factors such as underlying malignancy, remission state or the genetic background might also impact on the risk and severity of infection. Initial antibacterial treatment as well as modification and cessation of therapy depends on clinical performance, microbiological findings and haematological recovery. Although paediatric specific guidelines have been developed in the last decade, a number of questions are still unsolved. This article gives an overview on diagnostics and management of paediatric patients presenting with febrile neutropenia, on research gaps and will speculate on future perspective.

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