Brillouin Spectroscopy in Ophthalmology

Seiler, Theo G; Geerling, Gerd (2023). Brillouin Spectroscopy in Ophthalmology. Klinische Monatsblätter für Augenheilkunde, 240(6), pp. 779-782. Thieme 10.1055/a-2085-5738

[img]
Preview
Text
a-2085-5738.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (135kB) | Preview

Background: Information about corneal biomechanics is crucial for achieving satisfactory outcomes after surgical corneal interventions, e.g., for astigmatic keratotomies, but also to identify corneas that are at risk for postoperative complications such as corneal ectasia. Hitherto, approaches to characterize corneal biomechanics in an in vivo setting have yielded only minor success, demonstrating the unmet medical need for a diagnostic technique to measure ocular biomechanics.

Objective: This review shall explain the mechanism of Brillouin spectroscopy and summarize the current scientific knowledge for ocular tissue.

Methods: PubMed research of relevant experimental and clinical publications, as well as reporting of own experience using Brillouin spectroscopy.

Results: Brillouin spectroscopy can measure different biomechanical moduli with a high spatial resolution. Currently, available devices are able to detect focal corneal weakening, e.g., in keratoconus, as well as stiffening after corneal cross-linking. Also, the mechanical properties of the crystalline can be measured. Corneal anisotropy and hydration, together with the dependence on the angle of the incident laser beam in Brillouin spectroscopy, are challenges in the precise interpretation of measured data. A clear advantage in the detection of subclinical keratoconus compared to corneal tomography, however, has not been shown yet.

Conclusion: Brillouin spectroscopy is a technique to characterize biomechanical properties of ocular tissue in vivo. Published results confirm ex vivo data of ocular biomechanics; however, further improvements in the acquisition and interpretation of measured data are required until this technique can be used in a clinically viable setting.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Seiler, Günter Theodor Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-3999

Publisher:

Thieme

Language:

German

Submitter:

Demetra Olariu

Date Deposited:

09 Jan 2024 10:37

Last Modified:

24 Jun 2024 00:25

Publisher DOI:

10.1055/a-2085-5738

PubMed ID:

37142238

Uncontrolled Keywords:

Kornea - Biomechanik - Keratokonus - Ophthalmologie - Brillouin

BORIS DOI:

10.48350/191359

URI:

https://boris.unibe.ch/id/eprint/191359

Actions (login required)

Edit item Edit item
Provide Feedback