Karousis, Evangelos D; Schubert, Katharina; Ban, Nenad (2024). Coronavirus takeover of host cell translation and intracellular antiviral response: a molecular perspective. The EMBO journal, 43(2), pp. 151-167. EMBO Press 10.1038/s44318-023-00019-8
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Coronaviruses are a group of related RNA viruses that cause respiratory diseases in humans and animals. Understanding the mechanisms of translation regulation during coronaviral infections is critical for developing antiviral therapies and preventing viral spread. Translation of the viral single-stranded RNA genome in the host cell cytoplasm is an essential step in the life cycle of coronaviruses, which affects the cellular mRNA translation landscape in many ways. Here we discuss various viral strategies of translation control, including how members of the Betacoronavirus genus shut down host cell translation and suppress host innate immune functions, as well as the role of the viral non-structural protein 1 (Nsp1) in the process. We also outline the fate of viral RNA, considering stress response mechanisms triggered in infected cells, and describe how unique viral RNA features contribute to programmed ribosomal -1 frameshifting, RNA editing, and translation shutdown evasion.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Karousis, Evangelos |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1460-2075 |
Publisher: |
EMBO Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Jan 2024 10:46 |
Last Modified: |
18 Jan 2024 00:17 |
Publisher DOI: |
10.1038/s44318-023-00019-8 |
PubMed ID: |
38200146 |
Uncontrolled Keywords: |
Coronaviruses SARS-CoV-2 Translation Translation regulation Viral protein synthesis |
BORIS DOI: |
10.48350/191476 |
URI: |
https://boris.unibe.ch/id/eprint/191476 |
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