Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet

Sauter, S N; Benyacoub, J; Allenspach, K; Gaschen, F; Ontsouka, E; Reuteler, G; Cavadini, C; Knorr, R; Blum, J W (2006). Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet. Journal of animal physiology and animal nutrition, 90(7-8), pp. 269-77. Berlin: Blackwell Science 10.1111/j.1439-0396.2005.00595.x

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We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and on microbiota. Twenty-one client-owned dogs with FRD were presented for clinically needed duodeno- and colonoscopy and were enrolled in a prospective placebo (PL)-controlled probiotic trial. Intestinal tissue samples and faeces were collected during endoscopy. Intestinal mRNA abundance of interleukin (IL)-5, -10, -12p40 and -13, tumour necrosis factor-alpha, transforming growth factor-beta1 and interferon (IFN)-gamma were analysed and numbers of Lactobacillus spp., Bifidobacterium spp., Enterococcus spp. and Enterobacteriaceae and supplemented probiotic bacteria were determined in faeces. The Canine Inflammatory Bowel Disease Activity Index, a scoring system comprising general attitude, appetite, faecal consistency, defecation frequency, and vomitus, decreased in all dogs (p < 0.0001). Duodenal IL-10 mRNA levels decreased (p = 0.1) and colonic IFN-gamma mRNA levels increased (p = 0.08) after probiotic treatment. Numbers of Enterobacteriaceae decreased in FRD dogs receiving probiotic cocktail (FRD(PC)) and FRD dogs fed PL (FRD(PL)) during treatment (p < 0.05), numbers of Lactobacillus spp. increased in FRD(PC after) when compared with FRD(PC before) (p < 0.1). One strain of PC was detected in five of eight FRD(PC) dogs after probiotic supplementation. In conclusion, all dogs clinically improved after treatment, but cytokine patterns were not associated with the clinical features irrespective of the dietary supplementation.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Sauter, S.; Allenspach, K.; Gaschen, F; Ontsouka, Corneille Edgar and Blum, Jürg

ISSN:

0931-2439

Publisher:

Blackwell Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

21 Jan 2014 15:06

Publisher DOI:

10.1111/j.1439-0396.2005.00595.x

PubMed ID:

16867072

Web of Science ID:

000238838300001

URI:

https://boris.unibe.ch/id/eprint/19166 (FactScience: 1578)

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