Tortajada, Andreu; Hevia, Eva (2023). Alkali-metal bases in catalytic hydrogen isotope exchange processes. Catalysis science & technology, 13(17), pp. 4919-4925. Royal Society of Chemistry 10.1039/d3cy00825h
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he preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of transition metal catalysis, alkali-metal bases, used as catalysts or under stoichiometric conditions, have also emerged as a viable alternative. In this minireview we describe the latest advances in the use of alkali-metal bases in HIE processes, showcasing their synthetic potential as well as current challenges in the field. It is divided in different sections based on the isotope source used, emphasizing their benefits, disadvantages and limitations. The influence on the choice of alkali-metal in these processes as well as their possible mechanistic pathways are also discussed.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Tortajada Navarro, Andreu, Hevia Freire, Eva |
Subjects: |
500 Science > 540 Chemistry |
ISSN: |
2044-4753 |
Publisher: |
Royal Society of Chemistry |
Language: |
English |
Submitter: |
Franziska Bornhauser-Rufer |
Date Deposited: |
18 Jan 2024 09:06 |
Last Modified: |
18 Jan 2024 09:15 |
Publisher DOI: |
10.1039/d3cy00825h |
BORIS DOI: |
10.48350/191734 |
URI: |
https://boris.unibe.ch/id/eprint/191734 |
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