[Invasive meningococcal infections: two cases that demonstrate the broad spectrum in clinical manifestation and outcome]

Boscacci, Rémy; Leib, Stephen L. (2006). [Invasive meningococcal infections: two cases that demonstrate the broad spectrum in clinical manifestation and outcome]. Praxis - schweizerische Rundschau für Medizin, 95(43), pp. 1675-1678. Bern: Huber 10.1024/1661-8157.95.43.1675

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Invasive meningococcal infections show a broad clinical picture including sepsis and meningitis. Here we report on a case of sepsis and a case of meningitis, two clinical manifestations of meningococcal infections with striking differences in the clinical presentation and outcome. Meningococcal sepsis is characterized by a systemic release of endotoxins, that triggers an intense cytokine response of the host that can lead to shock and multi organ failure and death within hours. Meningococcal meningitis occurs when bacteria breach into the subarachnoidal and ventricular space during bacteremia and mortality is much lower that in sepsis. Thus meningitis may be seen as a consequence of lower pathogenicity and/or more efficient host control of the meningococci compared to sepsis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Boscacci, Rémy and Leib, Stephen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-8157

ISBN:

17111853

Publisher:

Huber

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

30 Jul 2016 19:44

Publisher DOI:

10.1024/1661-8157.95.43.1675

PubMed ID:

17111853

BORIS DOI:

10.7892/boris.19176

URI:

https://boris.unibe.ch/id/eprint/19176 (FactScience: 1597)

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