Blondiaux, Eva; Diamantaras, Andreas; Schumacher, Rahel; Blanke, Olaf; Müri, René; Heydrich, Lukas (2024). The neural correlates of topographical disorientation-a lesion analysis study. Annals of Clinical and Translational Neurology, 11(2), pp. 520-524. Wiley 10.1002/acn3.51967
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Ann_Clin_Transl_Neurol_-_2024_-_Blondiaux_-_The_neural_correlates_of_topographical_disorientation_a_lesion_analysis_study.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (297kB) | Preview |
Topographical disorientation refers to the selective inability to orient oneself in familiar surroundings. However, to date its neural correlates remain poorly understood. Here we use quantitative lesion analysis and a lesion network mapping approach in order to investigate seven patients with topographical disorientation. Our findings link not only the posterior parahippocampal gyrus (PHG) and retrosplenial cortex but also the lingual gyrus, the precuneus and the fusiform gyrus to topographical disorientation. We propose that topographical disorientation is due to the inability to integrate familiar landmarks within a framework of allocentric and egocentric orientation, supported by a neural network including the posterior PHG, the retrosplenial and the lingual cortex.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Diamantaras, Andreas Antonios, Schumacher, Rahel, Müri, René Martin, Heydrich, Lukas Emmanuel Josef Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2328-9503 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Jan 2024 10:00 |
Last Modified: |
14 Feb 2024 00:16 |
Publisher DOI: |
10.1002/acn3.51967 |
PubMed ID: |
38234234 |
BORIS DOI: |
10.48350/191775 |
URI: |
https://boris.unibe.ch/id/eprint/191775 |
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