The non to moderately dilated root in acute type a aortic dissection: outcomes of the PENN-BERN registry in young, non-syndromic patients.

Mosbahi, Selim; Siepe, Matthias R; Desai, Nimesh D; Pregaldini, Fabio; Nucera, Maria; Berezowski, M; Kelly, John J; Jiang, Fei; Zhao, Yu; Szeto, Wilson Y; Schoenhoff, Florian S; Bavaria, Joseph E (2024). The non to moderately dilated root in acute type a aortic dissection: outcomes of the PENN-BERN registry in young, non-syndromic patients. European journal of cardio-thoracic surgery, 65(1) Oxford University Press 10.1093/ejcts/ezae024

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OBJECTIVES

There is an ongoing debate regarding whether patients benefit more from root replacement compared to a reconstruction of the sinuses of Valsalva in acute type A aortic dissection. In those with known or suspected connective tissue disorders, root replacement is considered appropriate. However, there are currently no diameter-based guidelines regarding the best approach in patients with minimally to moderately dilated root and no connective tissue disorders.

METHODS

From January 2005 to December 2022, a two-center registry of acute type A aortic dissection was created. Patients were included based on their age (≤60 years), the absence of root entry and dilatation >50mm, the absence of syndromic hereditable aortic disease. Patients were divided into 2 groups based on the proximal procedure, root reconstruction and root replacement. Propensity score pair matching was performed based on preoperative characteristics.

RESULTS

Cumulative incidence of reintervention at 10 years was slightly higher after root reconstruction 13% vs 3.9% in the matched group (p = 0.040). Survival at 10 years was not affected by the procedure independently of the matching 72.1% vs 71.4% (p = 0.2). Uni- and multivariate Cox regression showed that a root diameter of > 40mm was associated with a hazard ratio of 7.7 (95% confidence interval 2.6-23) and 5.4 (7-17) respectively, for reoperation for aneurysm and pseudoaneurysm.

CONCLUSIONS

Rate of reoperation due to proximal pseudoaneurysm and aneurysm could be significantly reduced with a lower threshold of 40 mm to replace the aortic root in acute type A aortic dissection than in elective cases.

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