Egeberg, Alexander; Schlapbach, Christoph; Haugaard, Jeanette Halskou; Nymand, Lea; Thein, David; Thomsen, Simon Francis; Thyssen, Jacob P (2024). Adverse events from topical corticosteroid use in chronic hand eczema - Findings from the Danish Skin Cohort. JAAD international, 14, pp. 77-83. Elsevier 10.1016/j.jdin.2023.11.004
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BACKGROUND
Topical corticosteroids (TCS) are used to treat most patients with chronic hand eczema (CHE), but knowledge about TCS-related adverse events in CHE is limited.
OBJECTIVES
To investigate patient-reported adverse events to TCS in CHE patients.
METHODS
Data on adverse events related to TCS use in patients with CHE were analyzed from the Danish Skin Cohort; a prospective survey of a hospital cohort. We assessed patients' knowledge about TCS use and adverse event risks, and preference of TCS versus a nonsteroidal topical alternative.
RESULTS
Of 724 adults with CHE (64.0% women; mean age 57.5 [standard deviation 12.8] years), 64.1% reported skin atrophy, 41.4% cracks/fissures, 23.9% bleeding, 45.9% pain/stinging sensation, 40.0% reduced hand dexterity, and 40.2% worsening of CHE signs or symptoms from using TCS. We observed CHE-severity-dependent associations (all groups; P < .0001). Most patients (76.4%) would prefer a nonsteroidal option, 10.9% were neutral/indifferent, and 12.7% would prefer TCS for CHE. The median numerical rating scale-score (ranging from 0 to 10) was 10 (interquartile range 6-10) for preferring a nonsteroidal topical treatment.
LIMITATIONS
Differences across TCS formulations were unexplored.
CONCLUSION
TCS-related cutaneous adverse events were common. There is a desire from patients for novel steroid-free topical alternatives for CHE treatment.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Schlapbach, Christoph |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2666-3287 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Jan 2024 15:35 |
Last Modified: |
26 Jan 2024 15:44 |
Publisher DOI: |
10.1016/j.jdin.2023.11.004 |
PubMed ID: |
38274394 |
Uncontrolled Keywords: |
Danish Skin Cohort adverse events chronic hand eczema side effects topical corticosteroids |
BORIS DOI: |
10.48350/192159 |
URI: |
https://boris.unibe.ch/id/eprint/192159 |
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