Rossier, Laura N; Décosterd, Natalie P; Matter, Christoph B; Staudenmann, Dominic A; Moser, André; Egger, Bernhard; Seibold, Frank W (2024). SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study. Annals of medicine, 56(2295979) Taylor & Francis 10.1080/07853890.2023.2295979
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SARS-CoV-2_vaccination_in_inflammatory_bowel_disease_patients_is_not_associated_with_flares_a_retrospective_single-centre_Swiss_study.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview |
INTRODUCTION
Vaccination hesitancy is an important barrier to vaccination among IBD patients. The development of adverse events is the main concern reported. The purpose of this monocentric study was to assess SARS-CoV-2 vaccination safety in IBD patients by evaluating the postvaccination flare risk and incidence of overall adverse events.
METHODS
Surveys were handed out on three consecutive months to each patient presenting at the Crohn-Colitis Centre, where they documented their vaccination status and any side effects experienced after vaccination.Dates of flares occurring in 2021 were recorded from their electronic medical records. Baseline and IBD characteristics and flare incidence were compared between the vaccinated and unvaccinated patients, and among the vaccinated population before and after their vaccination doses. The characteristics of patients who developed side effects and of those who did not were compared.
RESULTS
We enrolled 396 IBD patients, of whom 91% were vaccinated. The proportion of patients who experienced flares was statistically not different between the vaccinated and the unvaccinated population (1.8 vs 2.6 flares per 100 person-months (p = 0.28)). Among vaccinated patients, there was no difference across the prevaccination, 1 month post any vaccination, and more than 1 month after any vaccination periods, and between the Spikevax and Cominarty subgroups. Overall, 46% of patients reported vaccination side effects, mostly mild flu-like symptoms.
CONCLUSION
SARS-CoV-2 vaccination with mRNA vaccines seems safe, with mostly mild side effects. The IBD flare risk is not increased in the month following any vaccination.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) |
UniBE Contributor: |
Moser, André |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1365-2060 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
31 Jan 2024 07:40 |
Last Modified: |
20 Feb 2024 14:15 |
Publisher DOI: |
10.1080/07853890.2023.2295979 |
PubMed ID: |
38289017 |
Uncontrolled Keywords: |
Flares IBD SARS-CoV-2 vaccination |
BORIS DOI: |
10.48350/192282 |
URI: |
https://boris.unibe.ch/id/eprint/192282 |
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