EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration

Nagakane, Yoshinari; Christensen, Soren; Brekenfeld, Caspar; Ma, Henry; Churilov, Leonid; Parsons, Mark W; Levi, Christopher R; Butcher, Kenneth S; Peeters, Andre; Barber, P Alan; Bladin, Christopher F; De Silva Deidre, A; Fink, John; Kimber, Thomas E; Schultz, David W; Muir, Keith W; Tress, Brian M; Desmond, Patricia M; Davis, Stephen M; Donnan Geoffrey, A; ... (2011). EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. Stroke, 42(1), pp. 59-64. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/STROKEAHA.110.580464

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the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) was a prospective, randomized, double-blinded, placebo-controlled, phase II trial of alteplase between 3 and 6 hours after stroke onset. The primary outcome of infarct growth attenuation on MRI with alteplase in mismatch patients was negative when mismatch volumes were assessed volumetrically, without coregistration, which underestimates mismatch volumes. We hypothesized that assessing the extent of mismatch by coregistration of perfusion and diffusion MRI maps may more accurately allow the effects of alteplase vs placebo to be evaluated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Brekenfeld, Caspar

ISSN:

0039-2499

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

17 Mar 2015 19:12

Publisher DOI:

10.1161/STROKEAHA.110.580464

PubMed ID:

21127303

Web of Science ID:

000285636400017

URI:

https://boris.unibe.ch/id/eprint/1923 (FactScience: 204007)

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