Nissen, Gyde; Hinsenbrock, Svenja; Rausch, Tanja K; Stichtenoth, Guido; Ricklefs, Isabell; Weckmann, Markus; Franke, Andre; Herting, Egbert; König, Inke R; Kopp, Matthias V; Rabe, Klaus F; Göpel, Wolfgang (2023). Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD. NEJM Evidence, 2(3) NEJM Group 10.1056/EVIDoa2200279
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Lung Function of Preterm Children by COPD PRSPolygenic risk score (PRS) for FEV1 and FVC was calculated in children born prematurely. COPD risk score was strongly associated with FEV1 (-0.05 z score/decile, P=6.5 × 10-9) and FEV1/FVC (-0.07 z score/decile, P=4.4 × 10-11) but not FVC. Children at highest risk had lower lung function by these measures and higher rates of obstructive bronchitis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Kopp, Matthias Volkmar |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2766-5526 |
Publisher: |
NEJM Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Feb 2024 09:07 |
Last Modified: |
08 Feb 2024 13:08 |
Publisher DOI: |
10.1056/EVIDoa2200279 |
PubMed ID: |
38320054 |
BORIS DOI: |
10.48350/192637 |
URI: |
https://boris.unibe.ch/id/eprint/192637 |
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