Hajiyev, Kamran; Henkes, Hans; Khanafer, Ali; Bücke, Philipp; Hennersdorf, Florian; Bäzner, Hansjörg; von Gottberg, Philipp (2024). Drug-Coated Balloons for Treatment of Internal Carotid Artery Restenosis After Stenting: A Single-Center Mid-Term Outcome Study. Cardiovascular and interventional radiology, 47(3), pp. 291-298. Springer-Verlag 10.1007/s00270-024-03663-7
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PURPOSE
Endovascular and surgical treatments of stenosis of the extracranial internal carotid artery (ICA) are common procedures, yet both introduce a risk of restenosis due to endothelial hyperplasia. Drug-coated balloons (DCBs) are designed to decrease neointimal hyperplasia, however rarely used in the neurovascular setting. This study retrospectively analyzes mid-term results of DCB-treated in-stent restenosis (ISR) of the ICA.
MATERIALS AND METHODS
The medical history, comorbidities, and periprocedural data of patients receiving DCB treatment for > 50% ISR of the ICA after carotid artery stenting were analyzed. Follow-up after DCB treatment was performed with Doppler ultrasound. Suspicious cases were checked with CT- or MR-angiography and-if there was agreement between the modalities-validated with digital subtraction angiography. Potential risk factors for restenosis and differences in outcomes after PTA with three types of DCB balloons were evaluated.
RESULTS
DCB treatment was performed in 109 cases, 0.9% of which involved in-hospital major stroke; no minor strokes occurred. A total of 17 patients (15.6%) had recurrent ISR after DCB treatment, after a mean time of 30.2 months (7-85 months). Tobacco use was significantly associated with a higher incidence of recurrent ISR.
CONCLUSION
DCB angioplasty for ISR is an effective treatment that may delay and decrease restenosis. Treating comorbidities and adopting lifestyle changes may additionally help prevent ISR.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Bücke, Philipp Jonas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0174-1551 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Feb 2024 11:40 |
Last Modified: |
09 Mar 2024 00:15 |
Publisher DOI: |
10.1007/s00270-024-03663-7 |
PubMed ID: |
38326576 |
Uncontrolled Keywords: |
Carotid artery atherosclerotic disease Carotid artery stenting Drug-coated balloons In-stent restenosis Stroke |
BORIS DOI: |
10.48350/192678 |
URI: |
https://boris.unibe.ch/id/eprint/192678 |
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