Augspach, Anke; Rubin, Mark A (2024). Upcycling HOXB13: enhancing prostate cancer detection with a novel antibody†. The journal of pathology: clinical research, 262(4), pp. 391-394. Wiley 10.1002/path.6258
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The_Journal_of_Pathology_-_2024_-_Augspach_-_Upcycling_HOXB13__enhancing_prostate_cancer_detection_with_a_novel_antibody.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (691kB) | Preview |
Prostate cancer is one of the most prevalent and, upon metastasis, deadliest cancers in men. Timely identification is essential for effective treatment. Furthermore, accurate determination of prostatic origin is crucial for personalized therapy once the cancer has spread. However, current prostate cancer screening methods are lacking. A recent article in The Journal of Pathology addresses this issue by utilizing an improved antibody to reevaluate HOXB13 as a lineage marker for prostate cancer. The study's findings support the concept that, despite decreased expression in advanced prostate cancer, HOXB13 remains highly suitable for determining prostatic origin due to its androgen receptor independence, high specificity, and sensitivity. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Augspach, Anke Katharina, Rubin, Mark Andrew |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2056-4538 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Feb 2024 09:14 |
Last Modified: |
06 Mar 2024 00:15 |
Publisher DOI: |
10.1002/path.6258 |
PubMed ID: |
38332742 |
Uncontrolled Keywords: |
HOXB13 androgen receptor lineage marker neuroendocrine prostate cancer precision oncology prostate cancer |
BORIS DOI: |
10.48350/192727 |
URI: |
https://boris.unibe.ch/id/eprint/192727 |
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