Kasper, Bernd; Pink, Daniel; Rothermundt, Christian; Richter, Stephan; Augustin, Marinela; Kollar, Attila; Kunitz, Annegret; Eisterer, Wolfgang; Gaidzik, Verena; Brodowicz, Thomas; Egerer, Gerlinde; Reichardt, Peter; Hohenberger, Peter; Schuler, Markus K (2024). Geriatric Assessment of Older Patients Receiving Trabectedin in First-Line Treatment for Advanced Soft Tissue Sarcomas: The E-TRAB Study from The German Interdisciplinary Sarcoma Group (GISG-13). Cancers, 16(3) MDPI AG 10.3390/cancers16030558
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E-TRAB was a non-interventional, prospective trial investigating the feasibility and predictive value of geriatric assessments (GA) in older STS patients treated with trabectedin as first-line therapy. Primary endpoints were overall survival (OS), quality of life and individual clinical benefit assessed by the patient-reported outcome measures QLQ-C30 and PRO-CTCAE. Further, several GA tools were applied and correlated with clinical outcomes and treatment-related toxicities. The final analyses included 69 patients from 12 German-speaking sites. The median age of patients was 78 years (range: 55 to 88). Baseline data on PROs and GA identified a diverse population of older patients with respect to their global health status, although a large proportion of them suffered from limitations, required geriatric help and had a high risk of morbidity. The Cancer and Age Research Group (CARG) score classified 38%, 29% and 23% of the patients with low, intermediate and high risks for therapy-related side effects, respectively. Median OS was 11.2 months [95%CI: 5.6; 19.4]. The study confirmed that trabectedin as first-line treatment in older patients with STS has an acceptable and manageable safety profile. Potential prognostic factors for clinical outcome and therapy-related toxicity were identified among the GA tools. Long Timed Up and Go (TUG) showed a significant correlation to OS and early death, whereas a high CARG score (>9) was associated with an increase in unplanned hospitalizations and the incidence of toxicities grade ≥ 3.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Kollár, Attila |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Feb 2024 12:25 |
Last Modified: |
13 Feb 2024 12:34 |
Publisher DOI: |
10.3390/cancers16030558 |
PubMed ID: |
38339308 |
Uncontrolled Keywords: |
PRO STS geriatric assessment patient-reported outcome soft tissue sarcoma trabectedin |
BORIS DOI: |
10.48350/192764 |
URI: |
https://boris.unibe.ch/id/eprint/192764 |
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