A simple presurgical necrotizing enterocolitis-mortality scoring system

Kessler, U; Mungnirandr, A; Nelle, M; Nimmo, A F; Zachariou, Z; Berger, S (2006). A simple presurgical necrotizing enterocolitis-mortality scoring system. Journal of perinatology, 26(12), pp. 764-8. New York, N.Y.: Nature Publishing Group 10.1038/sj.jp.7211613

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OBJECTIVE: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). STUDY DESIGN: Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein). RESULTS: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively. CONCLUSION: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Kessler, Ulf; Nelle, Mathias and Zachariou, Zacharias

ISSN:

0743-8346

ISBN:

17122786

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

17 Mar 2015 21:46

Publisher DOI:

10.1038/sj.jp.7211613

PubMed ID:

17122786

Web of Science ID:

000242246000009

URI:

https://boris.unibe.ch/id/eprint/19278 (FactScience: 1777)

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