The relationship between coagulation and the extend of surgery and postoperative infection in surgical infants below 6 months of age

Kessler, Ulf; Guenther, Patrick; Zachariou, Zacharias (2006). The relationship between coagulation and the extend of surgery and postoperative infection in surgical infants below 6 months of age. Clinical hemorheology and microcirculation, 34(3), pp. 447-52. Amsterdam: IOS Press

Full text not available from this repository. (Request a copy)

AIM: First to assess coagulation changes after surgery in children below 6 months of age. Second to detect differences attributable to the extent of surgery and postoperative infection. MATERIALS AND METHODS: Blood counts, haemoglobin concentration (Hb), haematocrit (Ht), prothrombine time (PT), activated partial thromboplastine time (aPTT) and thrombelastography (TEG) were studied pre- and 2+/-1/2 d postoperatively. Patients were divided in 3 groups. I: minor surgery without access to the abdomen or thorax (n=51); II: abdominal or thoracic interventions (n=24); III: abdominal surgery with postoperative sepsis (n=11). RESULTS: Preoperative values of Hb, Ht and INR were related to the age of the infant. Postoperatively clot strength and formation rate increased in gr. I (p<0.05). In gr. II, clot formation was initiated earlier (p<0.05) even though PT decreased (p<0.05). In group III, patients postoperatively developed a tendency for hypocoagulability in all TEG-parameters, but not in plasmatic coagulation. Postoperative TEG measurements were significantly inferior in gr. III when compared to gr. I and II. CONCLUSION: Our findings suggest activation of whole blood coagulation in the uncomplicated postoperative period despite of a decrease in plasmatic coagulation. In sepsis, only thrombelastography, but not plasmatic coagulation was affected.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery

UniBE Contributor:

Kessler, Ulf, Zachariou, Zacharias

ISSN:

1386-0291

ISBN:

16614469

Publisher:

IOS Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

05 Dec 2022 14:14

PubMed ID:

16614469

Web of Science ID:

000236715300009

URI:

https://boris.unibe.ch/id/eprint/19279 (FactScience: 1778)

Actions (login required)

Edit item Edit item
Provide Feedback