Yulug, Burak; Ayyildiz, Sevilay; Sayman, Dila; Karaca, Ramazan; Ipek, Lutfiye; Cankaya, Seyda; Salar, Ali Behram; Ayyildiz, Behcet; Mikuta, Christian; Yagci, Nilay; Oktem, Ece Ozdemir; Ozsimsek, Ahmet; Velioglu, Halil Aziz; Hanoglu, Lutfu (2024). The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder. Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI), 10(e12450) Wiley on behalf of the Alzheimer's Association 10.1002/trc2.12450
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INTRODUCTION
Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms.
METHODS
We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as "amnestic" or "nonamnestic," based on the members' subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.
RESULTS
The right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.
DISCUSSION
The pulvinar may play a role in depression-related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2352-8737 |
Publisher: |
Wiley on behalf of the Alzheimer's Association |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Feb 2024 11:07 |
Last Modified: |
21 Feb 2024 04:08 |
Publisher DOI: |
10.1002/trc2.12450 |
PubMed ID: |
38356480 |
Uncontrolled Keywords: |
amnestic depression cognition depression functional magnetic resonance imaging pulvinar |
BORIS DOI: |
10.48350/192946 |
URI: |
https://boris.unibe.ch/id/eprint/192946 |
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