Optimizing the success of cell transplantation therapy for stroke

Bliss, Tonya M; Andres, Robert H; Steinberg, Gary K (2010). Optimizing the success of cell transplantation therapy for stroke. Neurobiology of disease, 37(2), pp. 275-83. Amsterdam: Elsevier 10.1016/j.nbd.2009.10.003

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Stem cell transplantation has evolved as a promising experimental treatment approach for stroke. In this review, we address the major hurdles for successful translation from basic research into clinical applications and discuss possible strategies to overcome these issues. We summarize the results from present pre-clinical and clinical studies and focus on specific areas of current controversy and research: (i) the therapeutic time window for cell transplantation; (ii) the selection of patients likely to benefit from such a therapy; (iii) the optimal route of cell delivery to the ischemic brain; (iv) the most suitable cell types and sources; (v) the potential mechanisms of functional recovery after cell transplantation; and (vi) the development of imaging techniques to monitor cell therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Andres, Robert

ISSN:

0969-9961

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.1016/j.nbd.2009.10.003

PubMed ID:

19822211

Web of Science ID:

000274224400006

URI:

https://boris.unibe.ch/id/eprint/193 (FactScience: 196864)

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