Cundiff, David K; Nigg, Claudio R. (2005). Diet and diabetic retinopathy: insights from the Diabetes Control and Complications Trial (DCCT). MedGenMed : Medscape general medicine, 7(1) Medscape
Full text not available from this repository.OBJECTIVE
We explore the influence of lifestyle on the progression of retinopathy.
DESIGN
Post hoc statistical analysis.
SUBJECTS/SETTING
One thousand forty-one patients with type 1 diabetes from 29 specialty clinics.
INTERVENTION
The Diabetes Control and Complications Trial (DCCT) lifestyle data (diet, exercise, and tobacco use) and retinopathy-related risk factors (mean arterial pressure, the low-density lipoprotein/high-density lipoprotein cholesterol ratio [LDL-C/HDL-C], serum triglycerides, glycosolated hemoglobin [HbA1c] levels, body mass index [BMI], and insulin utilization) were related to the rate of progression of retinopathy.
MAIN OUTCOME MEASURES
Correlation between lifestyle data with progression of retinopathy and retinopathy-related risk factors.
RESULTS
The percentage of calories as total fatty acids at baseline and overall positively correlated with prestudy and overall progression of retinopathy (r = .15, P < .0001 and r = .14, P < .0001, respectively). Average overall percentage of calories as dietary fiber inversely correlated with prestudy and overall progression of retinopathy (r = -.07, P = .0102 and r = -.10, P < .0002, respectively). The progression of retinopathy correlated with mean arterial pressure (prestudy r = .09, P = .0004 and overall r = .20, P < .0001), LDL-C/HDL-C (prestudy r = .13, P < .0001 and overall r = .15, P < .0001), serum triglycerides (prestudy r = .18, P < .0001 and overall r = .26, P < .0001), HbA1c (prestudy r = .10, P < .0001 and overall r = .45, P < .0001), BMI (prestudy r = .08, P <.0034 and overall r = .05, P = .08), insulin utilization (prestudy r = .19, P < .0001 and overall r = .14, P < .0001), tobacco use (prestudy r = .08, P < .0231 and overall r = .09, P < .0011), and the intensive vs conventional therapy study group (on-study r = -.27, P < .0001).
CONCLUSION
Tobacco use and diet, particularly the consumption of fatty acids and dietary fiber, are significantly associated with the rate of progression of diabetic retinopathy and retinopathy-related risk factors.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
07 Faculty of Human Sciences > Institute of Sport Science (ISPW) |
UniBE Contributor: |
Nigg, Claudio Renato |
Subjects: |
700 Arts > 790 Sports, games & entertainment |
ISSN: |
1531-0132 |
Publisher: |
Medscape |
Language: |
English |
Submitter: |
Claudio Renato Nigg |
Date Deposited: |
20 Jun 2024 08:29 |
Last Modified: |
01 Jul 2024 16:16 |
Related URLs: |
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PubMed ID: |
16369308 |
URI: |
https://boris.unibe.ch/id/eprint/193132 |
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