Karousis, Evangelos D. (2024). The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections. Biochemical Society transactions, 52(1), pp. 481-490. Portland Press 10.1042/BST20231119
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Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1 selectively inhibits host protein synthesis and induces mRNA degradation of host but not viral mRNAs and blocks nuclear mRNA export. The clinical implications of this protein are highlighted by showcasing the pathogenic role of Nsp1 through the repression of interferon expression pathways and the features of viral variants with mutations in the Nsp1 coding sequence. The ability of SARS-CoV-2 Nsp1 to hinder host immune responses at an early step, the absence of homology to any human proteins, and the availability of structural information render this viral protein an ideal drug target with therapeutic potential.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Karousis, Evangelos |
ISSN: |
0300-5127 |
Publisher: |
Portland Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Mar 2024 09:37 |
Last Modified: |
05 Mar 2024 09:44 |
Publisher DOI: |
10.1042/BST20231119 |
PubMed ID: |
38385526 |
Uncontrolled Keywords: |
COVID-19 Coronaviruses Nsp1 SARS-CoV-2 mRNA translation viral infection |
BORIS DOI: |
10.48350/193186 |
URI: |
https://boris.unibe.ch/id/eprint/193186 |
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