Reduction of postmortem angiography-induced tissue edema by using polyethylene glycol as a contrast agent dissolver

Jackowski, Christian; Bolliger, Stephan; Aghayev, Emin; Christe, Andreas; Kilchoer, Thomas; Aebi, Beat; Périnat, Therese; Dirnhofer, Richard; Thali, Michael J (2006). Reduction of postmortem angiography-induced tissue edema by using polyethylene glycol as a contrast agent dissolver. Journal of forensic sciences, 51(5), pp. 1134-7. Hoboken, N.J.: Wiley 10.1111/j.1556-4029.2006.00207.x

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Postmortem investigation is increasingly supported by computed tomography (CT) and magnetic resonance imaging, in which postmortem minimal invasive angiography has become important. The newly introduced approach using an aqueous contrast agent solution provided excellent vessel visualization but was suspected to possibly cause tissue edema artifacts in histological investigations. The aim of this study was to investigate on a porcine heart model whether it is possible to influence the contrast agent distribution within the soft tissue by changing its viscosity by dissolving the contrast agent in polyethylene glycol (PEG) as a matrix medium. High-resolution CT scans after injection showed that viscosities above c. 15 mPa s (65% PEG) prevented a contrast agent distribution within the capillary bed of the left ventricular myocardium. Thereby, the precondition of edema artifacts could be reduced. Its minimal invasive application on human corpses needs to be further adapted as the flow resistance is expected to differ between different tissues.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Management
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Imaging
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Jackowski, Christian; Bolliger, Stephan; Aghayev, Emin; Christe, Andreas; Aebi, Beat and Thali, Michael

ISSN:

0022-1198

ISBN:

17018094

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:47

Last Modified:

25 Jul 2014 08:02

Publisher DOI:

10.1111/j.1556-4029.2006.00207.x

PubMed ID:

17018094

Web of Science ID:

000240773700025

URI:

https://boris.unibe.ch/id/eprint/19320 (FactScience: 1852)

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