Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization

Jackowski, Christian; Christe, Andreas; Sonnenschein, Martin; Aghayev, Emin; Thali, Michael J (2006). Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization. European Heart Journal, 27(20), pp. 2459-67. Oxford: Oxford University Press 10.1093/eurheartj/ehl255

[img]
Preview
Text
ehl255.pdf - Published Version
Available under License Publisher holds Copyright.

Download (992kB) | Preview

AIMS: Postmortem magnetic resonance (MRI) imaging is currently evaluated as alternative to traditional autopsy and myocardial infarction plays a key role therein. The aim of this study is to determine the suitability of postmortem MRI in infarction age staging. METHODS AND RESULTS: In eight human forensic corpses presenting with a total of 11 myocardial infarcted areas, short-axis, transversal, and longitudinal long-axis images (T1, T2, stir, flair) were acquired in situ on a 1.5 T system. During subsequent autopsy, the section technique was adapted to short-axis images. Histological investigations were performed along the entire circumference of the left ventricle to correlate the signal alteration in MR to the histological appearance. Two peracute infarctions were not detected in MRI and autopsy. Four acute infarcted areas presented with decreased signal in necrotic centres and increased signal in marginal myocardial regions (T2-weighted). T1-weighted images showed local hyperintensities when intramyocardial haemorrhage occurred. Four cases showed subacute infarctions with hyperintense regions in T2-weighted images and no signal alteration in T1-weighted images. Four chronic myocardial infarctions showed distinctively decreased signals in all applied sequences. CONCLUSION: Postmortem MRI demonstrates myocardial infarction in situ and allows for an infarction age estimation based on the signal behaviour.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Management
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Jackowski, Christian, Christe, Andreas, Aghayev, Emin, Thali, Michael

ISSN:

0195-668X

ISBN:

16973689

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:47

Last Modified:

05 Dec 2022 14:14

Publisher DOI:

10.1093/eurheartj/ehl255

PubMed ID:

16973689

Web of Science ID:

000241092000020

BORIS DOI:

10.48350/19322

URI:

https://boris.unibe.ch/id/eprint/19322 (FactScience: 1855)

Actions (login required)

Edit item Edit item
Provide Feedback