Mercolli, Lorenzo; Bregenzer, Carola; Diemling, Markus; Mingels, Clemens; Rominger, Axel Oliver; Sari, Hasan; Seibel, Sigrid; Sohlberg, Antti; Viscione, Marco; Caobelli, Federico (2024). Internal dosimetry study of [82Rb]Cl using a long axial field-of-view PET/CT. (In Press). European journal of nuclear medicine and molecular imaging Springer 10.1007/s00259-024-06660-7
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PURPOSE
Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like 82Rb.
METHODS
We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [82Rb]Cl and were scanned dynamically for 7 min with a LAFOV PET/CT scanner.
RESULTS
Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 μGy/MBq (1.57 to 3.92 μGy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 μGy/MBq (3.22 to 5.37 μGy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 μGy/MBq (0.98 to 1.92 μGy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 μSv/MBq.
CONCLUSION
Our study suggests that the radiation dose associated with [82Rb]Cl PET/CT can be assessed by means of dynamic LAFOV PET and that it is lower compared to literature values.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Mercolli, Lorenzo, Bregenzer, Carola Maria, Mingels, Clemens, Rominger, Axel Oliver, Seibel, Sigrid Elisabeth, Caobelli, Federico |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1619-7089 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Feb 2024 12:47 |
Last Modified: |
28 Feb 2024 12:56 |
Publisher DOI: |
10.1007/s00259-024-06660-7 |
PubMed ID: |
38407598 |
Uncontrolled Keywords: |
Dosimetry Long axial field-of-view PET/CT Myocardial perfusion imaging Rubidium-82 |
BORIS DOI: |
10.48350/193441 |
URI: |
https://boris.unibe.ch/id/eprint/193441 |
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