Jordan, Olivier; Gan, Bee-Ha; Alwan, Sari; Perron, Karl; Sublet, Emmanuelle; Ducret, Verena; Ye, Hua; Borchard, Gerrit; Reymond, Jean-Louis; Patrulea, Viorica (2024). Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat Pseudomonas Aeruginosa. (In Press). Advanced healthcare materials(e2304118), e2304118. Wiley 10.1002/adhm.202304118
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Adv_Healthcare_Materials_-_2024_-_Jordan_-_Highly_Potent_Cationic_Chitosan_Derivatives_Coupled_to_Antimicrobial_Peptide.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview |
The burden of bacterial wound infections has considerably increased due to antibiotic resistance to most of the currently available antimicrobial drugs. Herein, we report for the first time a chemical coupling of two cationic N-aryl (pyridyl and aminocinnamyl) chitosan derivatives to antimicrobial peptide dendrimers (AMPDs) of different generations (first, second and third) via thioether-haloacetyl reaction. The new chitosan-AMPD conjugates showed high selectivity by killing Pseudomonas aeruginosa and very low toxicity towards mammalian cells, as well as extremely low hemolysis to red blood cells. Electron microscopy revealed that the new chitosan derivatives coupled to AMPD destroyed both the inner and outer membranes of Gram-negative P. aeruginosa. Moreover, chitosan-AMPD conjugates showed synergetic effects within extremely low concentrations. The new chitosan-AMPD conjugates can be used as potent antimicrobial therapeutic agents, to eradicate pathogens such as those present in acute and chronic infected wounds. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Gan, Bee Ha, Reymond, Jean-Louis |
Subjects: |
500 Science > 540 Chemistry 500 Science > 570 Life sciences; biology |
ISSN: |
2192-2659 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Feb 2024 10:49 |
Last Modified: |
29 Feb 2024 00:17 |
Publisher DOI: |
10.1002/adhm.202304118 |
PubMed ID: |
38412457 |
Uncontrolled Keywords: |
Chitosan derivatives Gram-negative P. aeruginosa antimicrobial agents antimicrobial peptide dendrimers (AMPDs) antimicrobial peptides (AMPs) |
BORIS DOI: |
10.48350/193533 |
URI: |
https://boris.unibe.ch/id/eprint/193533 |
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