Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Otth, Maria; Kasteler, Rahel; Mulder, Renée L; Agrusa, Jennifer; Armenian, Saro H; Barnea, Dana; Bergeron, Anne; Bhatt, Neel S; Bourke, Stephen J; Constine, Louis S; Goutaki, Myrofora; Green, Daniel M; Hennewig, Ulrike; Houdouin, Veronique; Hudson, Melissa M; Kremer, Leontien; Latzin, Philipp; Ng, Antony; Oeffinger, Kevin C; Schindera, Christina; ... (2024). Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. EClinicalMedicine, 69, p. 102487. Elsevier 10.1016/j.eclinm.2024.102487

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Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Group established and convened a panel of 33 experts to develop evidence-based surveillance guidelines. We critically reviewed available evidence regarding risk factors for pulmonary dysfunction, types of pulmonary function testing, and timings of surveillance, then we formulated our recommendations. We recommend that CAYA cancer survivors and healthcare providers are aware of reduced pulmonary function risks and pay vigilant attention to potential symptoms of pulmonary dysfunction, especially among survivors treated with allogeneic haematopoietic stem cell transplantation, thoracic radiotherapy, and thoracic surgery. Based on existing limited evidence and current lack of interventions, our panel recommends pulmonary function testing only for symptomatic survivors. Since scarce existing evidence informs our recommendation, we highlight the need for prospective collaborative studies to address pulmonary function knowledge gaps among CAYA cancer survivors.

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