Riederer, Franz; Beiersdorf, Johannes; Lang, Clemens; Pirker-Kees, Agnes; Klein, Antonia; Scutelnic, Adrian; Platho-Elwischger, Kirsten; Baumgartner, Christoph; Dreier, Jens P; Schankin, Christoph (2024). Signatures of migraine aura in high-density-EEG. Clinical neurophysiology, 160, pp. 113-120. Elsevier 10.1016/j.clinph.2024.01.008
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OBJECTIVE
Cortical spreading depolarization is highly conserved among the species. It is easily detectable in direct cortical surface recordings and has been recorded in the cortex of humans with severe neurological disease. It is considered the pathophysiological correlate of human migraine aura, but direct electrophysiological evidence is still missing. As signatures of cortical spreading depolarization have been recognized in scalp EEG, we investigated typical spontaneous migraine aura, using full band high-density EEG (HD-EEG).
METHODS
In this prospective study, patients with migraine with aura were investigated during spontaneous migraine aura and interictally. Time compressed HD-EEG were analyzed for the presence of cortical spreading depolarization characterized by (a) slow potential changes below 0.05 Hz, (b) suppression of faster activity from 0.5 Hz - 45 Hz (c) spreading of these changes to neighboring regions during the aura phase. Further, topographical changes in alpha-power spectral density (8-14 Hz) during aura were analyzed.
RESULTS
In total, 26 HD-EEGs were recorded in patients with migraine with aura, thereof 10 HD-EEGs during aura. Eight HD-EEGs were recorded in the same subject. During aura, no slow potentials were recorded, but alpha-power was significantly decreased in parieto-occipito-temporal location on the hemisphere contralateral to visual aura, lasting into the headache phase. Interictal alpha-power in patients with migraine with aura did not differ significantly from age- and sex-matched healthy controls.
CONCLUSIONS
Unequivocal signatures of spreading depolarization were not recorded with EEG on the intact scalp in migraine. The decrease in alpha-power contralateral to predominant visual symptoms is consistent with focal depression of spontaneous brain activity as a consequence of cortical spreading depolarization but is not specific thereof.
SIGNIFICANCE
Cortical spreading depolarization is relevant in migraine, other paroxysmal neurological disorders and neurointensive care.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Riederer, Franz, Klein, Antonia, Scutelnic, Adrian, Schankin, Christoph Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1872-8952 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Mar 2024 14:01 |
Last Modified: |
29 Mar 2024 00:15 |
Publisher DOI: |
10.1016/j.clinph.2024.01.008 |
PubMed ID: |
38422969 |
Uncontrolled Keywords: |
Cortical spreading depression High-Density EEG Migraine with aura Slow potential changes |
BORIS DOI: |
10.48350/193651 |
URI: |
https://boris.unibe.ch/id/eprint/193651 |
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