Muysers, Hannah; Chen, Hung-Ling; Hahn, Johannes; Folschweiller, Shani; Sigurdsson, Torfi; Sauer, Jonas-Frederic; Bartos, Marlene (2024). A persistent prefrontal reference frame across time and task rules. Nature communications, 15(2115) Nature Publishing Group 10.1038/s41467-024-46350-4
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Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or 'drifting' neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a 'core ensemble' of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Folschweiller, Shani |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2041-1723 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Mar 2024 15:59 |
Last Modified: |
11 Mar 2024 16:09 |
Publisher DOI: |
10.1038/s41467-024-46350-4 |
PubMed ID: |
38459033 |
BORIS DOI: |
10.48350/194089 |
URI: |
https://boris.unibe.ch/id/eprint/194089 |
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