Thomas, Rauen; Tenbrock, Klaus (2024). The role of cAMP dependent gene transcription in lupus pathophysiology. Clinical immunology, 262, p. 110179. Elsevier 10.1016/j.clim.2024.110179
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T lymphocytes play a major role in the pathophysiology of systemic lupus erythematosus. T cellular dysregulation includes significant alterations in signal transduction, cytokine production and metabolic pathways. The cAMP dependent transcription factors like CREB and CREM exert pleiotropic functions as they are critically involved in epigenetic conformational changes and gene regulation of different key effector cytokines in CD4+ T cells including that of IL2, IL17 and IL21 genes. In the present review we review current knowledge on altered expression and function of these factors in T cells that promote autoimmunity in SLE patients.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Rheumatology |
UniBE Contributor: |
Tenbrock, Klaus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1521-7035 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Mar 2024 14:35 |
Last Modified: |
13 Apr 2024 00:15 |
Publisher DOI: |
10.1016/j.clim.2024.110179 |
PubMed ID: |
38460896 |
Uncontrolled Keywords: |
CREB CREM alpha ICER Interleukin 2 Metabolism Th17 cAMP |
BORIS DOI: |
10.48350/194097 |
URI: |
https://boris.unibe.ch/id/eprint/194097 |
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