Fragiotta, Serena; Dysli, Chantal; Parravano, Mariacristina; Sacconi, Riccardo; Fantaguzzi, Federico; Servillo, Andrea; Severo, Alice Antonella; Tombolini, Beatrice; Costanzo, Eliana; De Geronimo, Daniele; Capuano, Vittorio; Souied, Eric; Bandello, Francesco; Querques, Giuseppe (2024). Phenotypic characterization of predictors for development and progression of geographic atrophy using optical coherence tomography. (In Press). Retina Wolters Kluwer 10.1097/IAE.0000000000004090
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phenotypic_characterization_of_predictors_for.622.pdf - Accepted Version Restricted to registered users only until 12 March 2025. Available under License Publisher holds Copyright. Download (1MB) | Request a copy |
PURPOSE
To evaluate the impact of optical coherence tomography (OCT) phenotypes preceding atrophy related to age-related macular degeneration (AMD) on the progression of atrophic lesions.
METHODS
In this observational retrospective cohort study, a total of 70 eyes of 60 consecutive patients with intermediate AMD with a minimum follow-up of 24 months were included. The atrophy was quantified using fundus autofluorescence, also considering the directionality of atrophy as centrifugal and centripetal progression rates.Main outcome measures were geographic atrophy (GA) progression rate (mm2/year) and square root-transformation GA (mm2/year).
RESULTS
The best-fit model for GA (OR: 1.81, p<0.001) and square root-transformation GA (OR: 1.36, p<0.001) areas revealed that the main baseline predictor was the presence of an RPE-basal lamina-(BL)-Bruch's membrane (BrM) splitting. Large drusen at baseline appeared protective for the GA area lesion expansion over time (OR: 0.52, p<0.001) when considered with other confounders.
CONCLUSION
A thin RPE-BL-BrM splitting without evidence of neovascularization on OCT angiography likely represents an OCT signature for late basal laminar deposits. Identifying this phenotype can help identify individuals with a higher risk of rapid progression and atrophy expansion.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Dysli, Chantal-Simone |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1539-2864 |
Publisher: |
Wolters Kluwer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Mar 2024 12:14 |
Last Modified: |
20 Mar 2024 12:23 |
Publisher DOI: |
10.1097/IAE.0000000000004090 |
PubMed ID: |
38471039 |
BORIS DOI: |
10.48350/194196 |
URI: |
https://boris.unibe.ch/id/eprint/194196 |
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