Timmermann, Beate; Alapetite, Claire; Dieckmann, Karin; Kortmann, Rolf-Dieter; Lassen-Ramshad, Yasmin; Maduro, John H; Ramos Albiac, Monica; Ricardi, Umberto; Weber, Damien C (2024). ESTRO-SIOPE guideline: Clinical management of radiotherapy in atypical teratoid/rhabdoid tumors (AT/RTs). Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 196, p. 110227. Elsevier Scientific Publ. Ireland 10.1016/j.radonc.2024.110227
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BACKGROUND AND PURPOSE
Treatment of patients with atypical teratoid/rhabdoid (AT/RT) is challenging, especially when very young (below the age of three years). Radiotherapy (RT) is part of a complex trimodality therapy. The purpose of this guideline is to provide appropriate recommendations for RT in the clinical management of patients not enrolled in clinical trials.
MATERIALS AND METHODS
Nine European experts were nominated to form a European Society for Radiotherapy and Oncology (ESTRO) guideline committee. A systematic literature search was conducted in PubMed/MEDLINE and Web of Science. They discussed and analyzed the evidence concerning the role of RT in the clinical management of AT/RT.
RESULTS
Recommendations on diagnostic imaging, therapeutic principles, RT considerations regarding timing, dose, techniques, target volume definitions, dose constraints of radiation-sensitive organs at risk, concomitant chemotherapy, and follow-up were considered. Treating children with AT/RT within the framework of prospective trials or prospective registries is of utmost importance.
CONCLUSION
The present guideline summarizes the evidence and clinical-based recommendations for RT in patients with AT/RT. Prospective clinical trials and international, large registries evaluating modern treatment approaches will contribute to a better understanding of the best treatment for these children in future.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Weber, Damien Charles |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1879-0887 |
Publisher: |
Elsevier Scientific Publ. Ireland |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Mar 2024 12:10 |
Last Modified: |
11 Jun 2024 00:13 |
Publisher DOI: |
10.1016/j.radonc.2024.110227 |
PubMed ID: |
38492671 |
Uncontrolled Keywords: |
Atypical teratoid rhabdoid tumor Brain tumor Children Radiotherapy |
BORIS DOI: |
10.48350/194383 |
URI: |
https://boris.unibe.ch/id/eprint/194383 |
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