Wurm, Juliane; Uka, Anita; Buettcher, Michael; Kottanattu, Lisa; Schöbi, Nina; Trück, Johannes; Villiger, Reto; Ritz, Nicole; Zimmermann, Petra (2024). Clinical and Laboratory Biomarkers as Predictors of Severity in Pediatric Inflammatory Multisystem Syndrome-temporally Associated With SARS-CoV-2: Data From a Prospective Nationwide Surveillance Study in Switzerland. (In Press). The pediatric infectious disease journal Wolters Kluwer Health 10.1097/INF.0000000000004332
Full text not available from this repository. (Request a copy)BACKGROUND
PIMS-TS (pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2) is a rare but serious condition in children following SARS-CoV-2 infection, characterized by a range of clinical symptoms with varying severity. Understanding risk factors for severe PIMS-TS is crucial for appropriate and timely intervention.
OBJECTIVE
To identify factors associated with increased PIMS-TS severity in children.
METHODS
In this nationwide prospective observational study, epidemiological and clinical data was collected from children <18 years of age with suspected or confirmed PIMS-TS from all 29 pediatric hospitals in Switzerland. Children were categorized into 3 groups according to admission to intensive care unit (ICU): non-ICU, ICU-moderate and ICU-severe, defined as requirement of invasive ventilation and/or inotropic support.
RESULTS
A total of 204 children were included; 99 (49%) were categorized as non-ICU, 50 (25%) as ICU-moderate and 55 (27%) as ICU-severe. In ICU-severe cases, respiratory and neurological symptoms were more frequent compared with non-ICU cases: 72% versus 47%, P < 0.001 and 66% versus 41%, P = 0.001, respectively. Compared with the non-ICU group, children in the ICU-severe group had lower lymphocyte counts, higher neutrophil-lymphocyte ratios, lower platelet counts, as well as higher C-reactive protein, N-terminal pro-B-type natriuretic peptide, troponin T and creatinine levels at admission. Lymphopenia and elevated troponin T levels at admission were associated with an increased risk of being in the ICU-severe group.
CONCLUSION
The severity of PIMS-TS may be predicted using clinical symptoms and laboratory biomarkers, which help clinicians in decision-making and management of patients.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology |
UniBE Contributor: |
Schöbi, Nina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1532-0987 |
Publisher: |
Wolters Kluwer Health |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Mar 2024 10:56 |
Last Modified: |
27 Mar 2024 10:56 |
Publisher DOI: |
10.1097/INF.0000000000004332 |
PubMed ID: |
38506504 |
URI: |
https://boris.unibe.ch/id/eprint/194581 |
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