Broumidis, Emmanouil; Paradisi, Francesca (2024). Engineering a Dual-Functionalized PolyHIPE Resin for Photobiocatalytic Flow Chemistry. Angewandte Chemie. International edition, 63(21), e202401912. Wiley 10.1002/anie.202401912
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Angew_Chem_Int_Ed_-_2024_-_Broumidis_-_Engineering_a_Dual_Functionalized_PolyHIPE_Resin_for_Photobiocatalytic_Flow.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview |
The use of a dual resin for photobiocatalysis, encompassing both a photocatalyst and an immobilized enzyme, brings several challenges including effective immobilization, maintaining photocatalyst and enzyme activity and ensuring sufficient light penetration. However, the benefits such as integrated processes, reusability, easier product separation, and potential for scalability can outweigh these challenges, making dual resin systems promising for efficient and sustainable photobiocatalytic applications. In this work we employ a photosensitizer-containing porous emulsion-templated polymer as a functional support that is used to covalently anchor a chloroperoxidase from Curvularia inaequalis (CiVCPO). We demonstrate the versatility of this heterogeneous photobiocatalytic material which enables the bromination of four aromatic substrates, including Rutin - a natural occurring flavonol - under blue light (456 nm) irradiation and continuous flow conditions.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Broumidis, Emmanouil, Paradisi, Francesca |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1521-3773 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Mar 2024 14:16 |
Last Modified: |
05 Jun 2024 11:36 |
Publisher DOI: |
10.1002/anie.202401912 |
PubMed ID: |
38507522 |
Uncontrolled Keywords: |
chloroperoxidase continuous flow photobiocatalysis photosensitizers rutin |
BORIS DOI: |
10.48350/194588 |
URI: |
https://boris.unibe.ch/id/eprint/194588 |
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