Engineering a Dual-Functionalized PolyHIPE Resin for Photobiocatalytic Flow Chemistry.

Broumidis, Emmanouil; Paradisi, Francesca (2024). Engineering a Dual-Functionalized PolyHIPE Resin for Photobiocatalytic Flow Chemistry. (In Press). Angewandte Chemie. International edition, e202401912. Wiley 10.1002/anie.202401912

Text Angew_Chem_Int_Ed_-_2024_-_Broumidis_-_Engineering_a_Dual_Functionalized_PolyHIPE_Resin_for_Photobiocatalytic_Flow.pdf - Accepted Version Restricted to registered users only until 21 March 2025. Available under License Publisher holds Copyright. Download (3MB) | Request a copy

The use of a dual resin for photobiocatalysis, encompassing both a photocatalyst and an immobilized enzyme, brings several challenges including effective immobilization, maintaining photocatalyst and enzyme activity and ensuring sufficient light penetration. However, the benefits such as integrated processes, reusability, easier product separation, and potential for scalability can outweigh these challenges, making dual resin systems promising for efficient and sustainable photobiocatalytic applications. In this work we employ a photosensitizer-containing porous emulsion-templated polymer as a functional support that is used to covalently anchor a chloroperoxidase from Curvularia inaequalis (CiVCPO). We demonstrate the versatility of this heterogeneous photobiocatalytic material which enables the bromination of four aromatic substrates, including Rutin - a natural occurring flavonol - under blue light (456 nm) irradiation and continuous flow conditions.

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