Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer.

Bertholet, Jenny; Mackeprang, Paul-Henry; Loebner, Hannes A; Mueller, Silvan; Guyer, Gian; Frei, Daniel; Volken, Werner; Elicin, Olgun; Aebersold, Daniel M; Fix, Michael K; Manser, Peter (2024). Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer. (In Press). Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 195(110237), p. 110237. Elsevier Scientific Publ. Ireland 10.1016/j.radonc.2024.110237

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We compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy.

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