Unlocking new dimensions in long-acting injectables using lipid mesophase-based beads.

Allegritti, Elena; Giansanti, Luisa; Bordon, Gregor; Maggi, Maria Anna; Luciani, Paola; Aleandri, Simone (2024). Unlocking new dimensions in long-acting injectables using lipid mesophase-based beads. Journal of colloid and interface science, 664, pp. 1031-1041. Elsevier 10.1016/j.jcis.2024.03.067

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In this study, we explored the use of lipid mesophases (LMPs) as a biocompatible and biodegradable material for sustained drug delivery. Our hypothesis centered on leveraging the high surface-to-volume ratio of LMP-based beads to enhance strength, stability, and surface interaction compared to the LMP bulk gel. To modulate drug release, we introduced antioxidant vitamin E into the beads, influencing mesophase topologies and controlling drug diffusion coefficients. Four drugs with distinct chemical properties and intended for three different pathologies and administration routes were successfully loaded into the beads with a drug entrapment efficiency exceeding 80 %. Notably, our findings revealed sustained drug release, irrespective of the drugs' chemical properties, culminating in the development of an injectable formulation. This formulation allows direct administration into the target site, minimizing systemic exposure, and thereby mitigating adverse effects. Our approach demonstrates the potential of LMP-based beads for tailored drug delivery systems with broad applications in diverse therapeutic scenarios.

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