Loser, Valentin; Baumgartner, Thomas; Legardeur, Hélène; Panchaud, Alice; Théaudin, Marie (2024). Patisiran exposure in early pregnancy: a case report. Therapeutic advances in neurological disorders, 17, p. 17562864241239755. Sage 10.1177/17562864241239755
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We describe here the first case of exposure to patisiran treatment, a small interfering RNA molecule, during early pregnancy of a 36-year-old woman with symptomatic hereditary transthyretin-related amyloidosis. There were no major complications during pregnancy and delivery, except for a postpartum hemorrhage due to uterine atony. Vitamin A levels had to be closely monitored during pregnancy, and vitamin A substitution adapted accordingly. There was no sign of minor or major congenital abnormalities of the baby. One month after delivery, the patient showed slight clinical and electrophysiological signs of neuropathy progression due to patisiran treatment withdrawal. Patisiran infusions were resumed 3 months after delivery. Due to the unknown teratogenic potential of patisiran, the risk of neuropathy worsening associated with withholding treatment must of course be weighed against a potential teratogenic risk of treatment during pregnancy. Vitamin A levels need to be closely assessed, and substitution must be adapted accordingly, to avoid embryofetal adverse outcome due to vitamin A deficiency or toxicity.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Panchaud Monnat, Alice Elke Martine |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1756-2856 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Apr 2024 13:55 |
Last Modified: |
03 Apr 2024 10:03 |
Publisher DOI: |
10.1177/17562864241239755 |
PubMed ID: |
38532802 |
Uncontrolled Keywords: |
Patisiran amyloidosis case report hATTR pregnancy siRNA |
BORIS DOI: |
10.48350/194955 |
URI: |
https://boris.unibe.ch/id/eprint/194955 |
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