Alterations of white matter integrity related to motor activity in schizophrenia

Walther, Sebastian; Federspiel, Andrea; Horn, Helge; Razavi, Nadja; Wiest, Roland; Dierks, Thomas; Strik, Werner; Müller, Thomas J (2011). Alterations of white matter integrity related to motor activity in schizophrenia. Neurobiology of disease, 42(3), pp. 276-83. Amsterdam: Elsevier 10.1016/j.nbd.2011.01.017

Full text not available from this repository.

Altered structural connectivity is a key finding in schizophrenia, but the meaning of white matter alterations for behavior is rarely studied. In healthy subjects, motor activity correlated with white matter integrity in motor tracts. To explore the relation of motor activity and fractional anisotropy (FA) in schizophrenia, we investigated 19 schizophrenia patients and 24 healthy control subjects using Diffusion Tensor Imaging (DTI) and actigraphy on the same day. Schizophrenia patients had lower activity levels (AL). In both groups linear relations of AL and FA were detected in several brain regions. Schizophrenia patients had lower FA values in prefrontal and left temporal clusters. Furthermore, using a general linear model, we found linear negative associations of FA and AL underneath the right supplemental motor area (SMA), the right precentral gyrus and posterior cingulum in patients. This effect within the SMA was not seen in controls. This association in schizophrenia patients may contribute to the well known dysfunctions of motor control. Thus, structural disconnectivity could lead to disturbed motor behavior in schizophrenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued]
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Walther, Sebastian, Federspiel, Andrea, Horn, Helge Joachim, Razavi, Nadja, Wiest, Roland Gerhard Rudi, Dierks, Thomas, Strik, Werner, Müller, Thomas (A)

ISSN:

0969-9961

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

29 Mar 2023 23:32

Publisher DOI:

10.1016/j.nbd.2011.01.017

PubMed ID:

21296665

Web of Science ID:

000290081700007

URI:

https://boris.unibe.ch/id/eprint/1953 (FactScience: 204053)

Actions (login required)

Edit item Edit item
Provide Feedback