Congestion patterns in severe tricuspid regurgitation and transcatheter treatment: Insights from a multicentre registry.

Rommel, Karl-Philipp; Bonnet, Guillaume; Fortmeier, Vera; Stolz, Lukas; Schöber, Anne R; von Stein, Jennifer; Kassar, Mohammad; Gerçek, Muhammed; Rosch, Sebastian; Stocker, Thomas J; Körber, Maria I; Kresoja, Karl-Patrik; Rudolph, Tanja K; Pfister, Roman; Baldus, Stephan; Windecker, Stephan; Thiele, Holger; Praz, Fabien; Hausleiter, Jörg; Rudolph, Volker; ... (2024). Congestion patterns in severe tricuspid regurgitation and transcatheter treatment: Insights from a multicentre registry. European journal of heart failure, 26(4), pp. 1004-1014. Wiley 10.1002/ejhf.3235

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AIMS

While invasively determined congestion holds mechanistic and prognostic significance in acute heart failure (HF), its role in patients with tricuspid regurgitation (TR)-related right- heart failure (HF) undergoing transcatheter tricuspid valve intervention (TTVI) is less well established. A comprehensive understanding of congestion patterns might aid in procedural planning, risk stratification, and the identification of patients who may benefit from adjunctive therapies before undergoing TTVI. The aim of this study was to investigate the role of congestion patterns in patients with severe TR and its implications for TTVI.

METHODS AND RESULTS

Within a multicentre, international TTVI registry, 813 patients underwent right heart catheterization (RHC) prior to TTVI and were followed up to 24 months. The median age was 80 (interquartile range 76-83) years and 54% were women. Both mean right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) were associated with 2-year mortality on Cox regression analyses with Youden index-derived cut-offs of 17 mmHg and 19 mmHg, respectively (p < 0.01 for all). However, RAP emerged as an independent predictor of outcomes following multivariable adjustments. Pre-interventionally, 42% of patients were classified as euvolaemic (RAP <17 mmHg, PCWP <19 mmHg), 23% as having left-sided congestion (RAP <17 mmHg, PCWP ≥19 mmHg), 8% as right-sided congestion (RAP ≥17 mmHg, PCWP <19 mmHg), and 27% as bilateral congestion (RAP ≥17 mmHg, PCWP ≥19 mmHg). Patients with right-sided or bilateral congestion had the lowest procedural success rates and shortest survival times. Congestion patterns allowed for discerning specific patient's physiology and specifying prognostic implications of right ventricular to pulmonary artery coupling surrogates.

CONCLUSION

In this large cohort of invasively characterized patients undergoing TTVI, congestion patterns involving right-sided congestion were associated with low procedural success and higher mortality rates after TTVI. Whether pre-interventional reduction of right-sided congestion can improve outcomes after TTVI should be established in dedicated studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Kassar, Mohammad, Windecker, Stephan, Praz, Fabien Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1879-0844

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

08 Apr 2024 15:38

Last Modified:

31 May 2024 00:14

Publisher DOI:

10.1002/ejhf.3235

PubMed ID:

38571456

Uncontrolled Keywords:

Central venous congestion Haemodynamics Right heart failure Transcatheter tricuspid valve repair Tricuspid regurgitation

BORIS DOI:

10.48350/195668

URI:

https://boris.unibe.ch/id/eprint/195668

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