Successful treatment of immune checkpoint inhibitor-related periaortitis

Bührer, Elias D; Alberts, Ian L; Christ, Lisa; Özdemir, Berna C (2024). Successful treatment of immune checkpoint inhibitor-related periaortitis. Swiss medical weekly, 154(2) SMW supporting association 10.57187/s.3631

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We report a 64-year-old patient with melanoma receiving ipilimumab and nivolumab therapy who presented with a periaortic soft tissue mass around the abdominal aorta on restaging fluorodeoxyglucose positron emission tomography/computed tomography imaging. Clinical, laboratory, and radiologic findings resulted in a diagnosis of immune checkpoint inhibitor-related periaortitis. Periaortitis is a rare disease presenting with fibro-inflammatory tissue around the aorta and may lead to serious complications. Immune checkpoint inhibitors were discontinued, and the patient was treated with glucocorticoids, leading to a complete resolution of the periaortitis. To our knowledge, this is only the third reported case of immune checkpoint inhibitor-related periaortitis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology

UniBE Contributor:

Bührer, Elias, Alberts, Ian Leigh, Christ, Lisa Alexandra, Özdemir, Berna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-3997

Publisher:

SMW supporting association

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

11 Apr 2024 08:31

Last Modified:

11 Apr 2024 08:31

Publisher DOI:

10.57187/s.3631

PubMed ID:

38579296

BORIS DOI:

10.48350/195686

URI:

https://boris.unibe.ch/id/eprint/195686

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