Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data.

Papazoglou, Anthia; Höhn, René; Schawkat, Megir; Tappeiner, Christoph; Iliev, Milko; Gugleta, Konstantin; Saletta, Giulia; Wiencierz, Andrea; Wagels, Barbara; Todorova, Margarita G; Krzyzanowska, Iwona; Töteberg-Harms, Marc; Tschopp, Markus (2024). Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data. Ophthalmology and therapy, 13(6), pp. 1513-1525. Springer 10.1007/s40123-024-00917-y

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INTRODUCTION

The aim of this study was to investigate the 2-year postoperative efficacy of the XEN45 Gel Stent by evaluating the reduction of intraocular pressure (IOP) and the need for eye pressure-lowering medications in a multicenter setting in Switzerland.

METHODS

Patients with various types of glaucoma who received a XEN45 Gel Stent with or without combined phacoemulsification cataract surgery at five hospitals in Switzerland were retrospectively enrolled. Pre- and postoperative IOP, the number of antiglaucoma medications, and the need of subsequent interventions to control IOP were assessed. The success rate was defined as a ≥ 20% reduction of IOP 2 years postoperatively without the need for subsequent glaucoma surgery.

RESULTS

A total of 345 eyes were included: 44.3% with primary open-angle, 42.0% pseudoexfoliation, and 13.7% with other types of glaucoma. Of these, 206 patients were followed for 2 years. Preoperatively, the mean IOP was 26.3 ± 8.9 mmHg and the mean number of antiglaucoma medications administered was 3.0 ± 1.3. Two years postoperatively, the success rate was 66.0% (95% confidence interval 59.3-72.1%), the IOP had dropped by 43.8% to 14.8 ± 5.7 mmHg, and the number of medications was reduced by a mean of 2.0 ± 1.7 per day. Postoperative complications and the need for interventions remained low.

CONCLUSION

The XEN45 Gel Stent successfully reduced IOP and the number of antiglaucoma drugs in most patients at 2 years postoperatively.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Höhn, René Gerhard Joachim, Schawkat, Megir, Tappeiner, Christoph, Iliev, Milko Emilov, Tschopp, Markus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2193-8245

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

08 Apr 2024 10:39

Last Modified:

22 May 2024 00:14

Publisher DOI:

10.1007/s40123-024-00917-y

PubMed ID:

38581605

Uncontrolled Keywords:

Implant Open angle glaucoma Pseudoexfoliation glaucoma Success rate XEN

BORIS DOI:

10.48350/195727

URI:

https://boris.unibe.ch/id/eprint/195727

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