Papazoglou, Anthia; Höhn, René; Schawkat, Megir; Tappeiner, Christoph; Iliev, Milko; Gugleta, Konstantin; Saletta, Giulia; Wiencierz, Andrea; Wagels, Barbara; Todorova, Margarita G; Krzyzanowska, Iwona; Töteberg-Harms, Marc; Tschopp, Markus (2024). Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data. (In Press). Ophthalmology and therapy Springer 10.1007/s40123-024-00917-y
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INTRODUCTION
The aim of this study was to investigate the 2-year postoperative efficacy of the XEN45 Gel Stent by evaluating the reduction of intraocular pressure (IOP) and the need for eye pressure-lowering medications in a multicenter setting in Switzerland.
METHODS
Patients with various types of glaucoma who received a XEN45 Gel Stent with or without combined phacoemulsification cataract surgery at five hospitals in Switzerland were retrospectively enrolled. Pre- and postoperative IOP, the number of antiglaucoma medications, and the need of subsequent interventions to control IOP were assessed. The success rate was defined as a ≥ 20% reduction of IOP 2 years postoperatively without the need for subsequent glaucoma surgery.
RESULTS
A total of 345 eyes were included: 44.3% with primary open-angle, 42.0% pseudoexfoliation, and 13.7% with other types of glaucoma. Of these, 206 patients were followed for 2 years. Preoperatively, the mean IOP was 26.3 ± 8.9 mmHg and the mean number of antiglaucoma medications administered was 3.0 ± 1.3. Two years postoperatively, the success rate was 66.0% (95% confidence interval 59.3-72.1%), the IOP had dropped by 43.8% to 14.8 ± 5.7 mmHg, and the number of medications was reduced by a mean of 2.0 ± 1.7 per day. Postoperative complications and the need for interventions remained low.
CONCLUSION
The XEN45 Gel Stent successfully reduced IOP and the number of antiglaucoma drugs in most patients at 2 years postoperatively.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Höhn, René Gerhard Joachim, Schawkat, Megir, Tappeiner, Christoph, Iliev, Milko Emilov, Tschopp, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2193-8245 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Apr 2024 10:39 |
Last Modified: |
08 Apr 2024 10:48 |
Publisher DOI: |
10.1007/s40123-024-00917-y |
PubMed ID: |
38581605 |
Uncontrolled Keywords: |
Implant Open angle glaucoma Pseudoexfoliation glaucoma Success rate XEN |
BORIS DOI: |
10.48350/195727 |
URI: |
https://boris.unibe.ch/id/eprint/195727 |
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