Riggenbach, Elena; Waser, Manuel; Mueller, Simon A; Aebersold, Daniel M; Giger, Roland; Elicin, Olgun (2024). Oncologic outcome with versus without target volume compartmentalization in postoperative radiotherapy for oral cavity squamous cell carcinoma. Frontiers in oncology, 14(1362025) Frontiers Research Foundation 10.3389/fonc.2024.1362025
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BACKGROUND AND PURPOSE
The volume treated with postoperative radiation therapy (PORT) in patients with oral cavity squamous cell carcinoma (OCSCC) is a mediator of toxicity affecting quality of life. Current guidelines only allow for very limited reduction of PORT volumes. This study investigated the safety and efficacy of de-intensified PORT for patients with OCSCC by refined compartmentalization of the treatment volume.
MATERIALS AND METHODS
This retrospective cohort study identified 103 OCSCC patients treated surgically from 2014 to 2019 with a loco-regional risk profile qualifying for PORT according to guidelines. PORT was administered only to the at-risk compartment and according to a refined compartmentalization concept (CC). Oncological outcome of this CC cohort was compared to a historical cohort (HC) of 98 patients treated before the CC was implemented.
RESULTS
Median follow-up time was 4.5 and 4.8 years in the CC and HC cohorts, respectively. In the CC cohort, a total of 72 of 103 patients (70%) had a pathological risk profile that allowed for further compartmentalization and, hence, received a reduced treatment volume or omission of PORT altogether. Loco-regional control at 3 and 5 years was 77% and 73% in the CC cohort versus 78% and 73% in the HC (p = 0.93), progression-free survival was 72% and 64% versus75% and 68% (p = 0.58), respectively. Similarly, no statistically significant difference was seen in other outcome measures.
CONCLUSIONS
De-intensified PORT limiting the treatment volume to the at-risk compartment or avoiding PORT altogether for low-risk patients with OCSCC does not seem to compromise disease control in this retrospective comparison. Based on these hypothesis-generating findings, a prospective study is being planned.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) |
UniBE Contributor: |
Riggenbach, Elena, Waser, Manuel Nicola, Müller, Simon Andreas, Aebersold, Daniel Matthias, Giger, Roland, Eliçin, Olgun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2234-943X |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Apr 2024 10:05 |
Last Modified: |
10 Apr 2024 19:56 |
Publisher DOI: |
10.3389/fonc.2024.1362025 |
PubMed ID: |
38590644 |
Uncontrolled Keywords: |
compartmentalization de-escalation head and neck cancer head and neck squamous cell carcinoma head and neck surgery oral cavity cancer postoperative radiotherapy radiotherapy |
BORIS DOI: |
10.48350/195818 |
URI: |
https://boris.unibe.ch/id/eprint/195818 |
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