Long-term follow-up after vertebroplasty - A mean 10-years follow-up control study.

Aregger, Fabian; Gerber, Felix; Albers, Christoph; Oswald, Katharina; Knoll, Christian; Benneker, Lorin; Heini, Paul; Berlemann, Ulrich; Hoppe, Sven (2024). Long-term follow-up after vertebroplasty - A mean 10-years follow-up control study. Brain and Spine, 4(102783) Elsevier 10.1016/j.bas.2024.102783

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To evaluate the clinical 10 year outcome of patients treated with percutaneous vertebroplasty for vertebral compression fractures and to determine the incidence of new fractures in this time interval, as well as the mortality of the patients who underwent this procedure.


All patients undergoing vertebroplasty for vertebral compression fractures between May 2007 until July 2008 were prospectively followed up at 10 years postoperatively. Patients were assessed for radiologic outcome and self-reported outcome parameters (PROs). Gathered parameters remained unmodified to the initial ones analyzing QoL improvement (EQ5D 3L and NASS score) and pain alleviation (VAS, NRS). Mortality was defined as an additional endpoint. Exclusion criteria include additional instrumentation, use of additional devices such as kyphoplasty balloons/stentoplasty, cognitive impairment, insufficient radiological documentation or absent re-consent.


Of 280 patients who underwent vertebroplasty, 49 (17.5%) were available for re-assessment with a mean follow-up of 10.5 years (9.9-11.1). Thirty patients (10.7%) were assessed clinically and radiologically, 16 (5.7%) in written form and three (1.1%) by phone only. A total of 186 (66.4%) died during the follow up period. Out of the remaining 45 patients, 27 patients declined participation, eight couldn't participate due to cognitive impairment, four had insufficient radiologic documentation. Six patients were lost to follow-up. At 10 years, patients reported a consistently improved quality of life (EQ-5D; p < 0.01) and global satisfaction. Vertebroplasty demonstrated a substantial and enduring effect on alleviating back pain over 10 years (p < 0.001). 26 (53%) patients experienced a new fracture since the initial procedure.


A decade following vertebroplasty, patients continue to demonstrate a quality of life and pain level comparable to short and medium-term assessments, with a significant difference from baseline measurements. More than half (53%) of the patients participating at last follow-up experienced new fractures during this interim period. The cohort as a whole has been impacted by an elevated mortality rate over the time period.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Aregger, Fabian, Albers, Christoph E., Oswald, Katharina Anna Christine, Benneker, Lorin Michael, Hoppe, Sven


600 Technology > 610 Medicine & health








Pubmed Import

Date Deposited:

16 Apr 2024 10:43

Last Modified:

17 Apr 2024 11:43

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Osteoporosis Thoracolumbar Trauma Vertebroplasty





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