Mueller, Daniel R.; Mueller-Szer, Rosa; Grossenbacher, Linda (4 April 2024). Prevention and prediction of relapse in schizophrenic patients: RCT results on integrative cognitive remediation during 8-year follow-up (Unpublished). In: 2024 annual congress of the Schizophrenia International Research Society SIRS. Florenz. 4.-7.4.2024.
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Background:
Relapses are a major burden for schizophrenic patients, their relatives and caregivers. Preventing and predicting relapses is therefore a serious challenge for psychiatric treatment.
Method:
In the present RCT study, the relapse prevention potential after a psychotherapeutic intervention in addition to standard treatment was investigated over 8 years. The used psychotherapy approach was Integrated Neurocognitive Therapy (INT), a group approach with interventions in 11 neuro- and social-cognitive domains, which are partly PC-supported including therapy elements from psychoeducation, CBTp and emotion as well as stress regulation. 71 outpatients with schizophrenia (diagnosed according to ICD-10) were assigned to either an INT group (30 sessions over 15 weeks) or a standard treatment (TAU). Relapse rates were evaluated during follow-up periods of 1, 5 and 8 years. A test battery was collected before and after treatment and at the 1-year follow-up.
Results:
The relapse rates for INT and TAU did not differ significantly in the first year. 5 and 8 years after the end of treatment, the relapse rates for INT (48%/52%) were significantly lower than for TAU (77.8%/82.8%). Rehospitalization days differed significantly too (8-year follow-up: INT=34.8 days; TAU=102.4 days). Predictors: During the 1-year follow-up, there was a significant correlation between higher relapse rates and lower social-cognitive performance levels (emotional processes, schemas). Relapse rates in the first year after completion of treatment predicted the course of relapses and rehospitalization days during the 5- and 8-year follow-up. At the 5- and 8-year follow-up, higher symptomatology, particularly positive symptoms, as well as higher levels of psychosocial functioning and verbal (working) memory were also found to be predictors of reduced rehospitalization days.
Discussion:
There seems to be evidence that INT can significantly reduce relapses and thus the days of rehospitalization compared to TAU over a longer observation period of 8 years. Predictors for this appear to be relapse rates, positive symptoms, psychosocial functioning and working memory after a 1-year follow-up.
Item Type: |
Conference or Workshop Item (Poster) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychotherapy |
UniBE Contributor: |
Müller, Daniel (B) |
Subjects: |
600 Technology > 610 Medicine & health |
Language: |
English |
Submitter: |
Daniel Müller |
Date Deposited: |
16 Apr 2024 14:25 |
Last Modified: |
26 Apr 2024 22:27 |
BORIS DOI: |
10.48350/196011 |
URI: |
https://boris.unibe.ch/id/eprint/196011 |
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