Perrais, Maïwenn; Trächsel, Bastien; Lenglet, Sébastien; Pruijm, Menno; Ponte, Belen; Vogt, Bruno; Augsburger, Marc; Rousson, Valentin; Bochud, Murielle; Thomas, Aurélien (2024). Reference values for plasma and urine trace elements in a Swiss population-based cohort. (In Press). Clinical chemistry and laboratory medicine Walter de Gruyter 10.1515/cclm-2023-1433
Full text not available from this repository. (Request a copy)OBJECTIVES
Trace elements (TEs) are ubiquitous. TE concentrations vary among individuals and countries, depending on factors such as living area, workplaces and diet. Deficit or excessive TEs concentrations have consequences on the proper functioning of human organism so their biomonitoring is important. The aim of this project was to provide reference values for TEs concentrations in the Swiss population.
METHODS
The 1,078 participants to the SKiPOGH cohort included in this study were aged 18-90 years. Their 24-h urine and/or plasma samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) to determine 24 TEs concentrations: Ag, Al, As, Be, Bi, Cd, Co, Cr, Cu, Hg, I, Li, Mn, Mo, Ni, Pb, Pd, Pt, Sb, Se, Sn, Tl, V and Zn. Statistical tests were performed to evaluate the influence of covariates (sex, age, BMI, smoking) on these results. Reference intervals for the Swiss adult population were also defined.
RESULTS
TEs concentrations were obtained for respectively 994 and 903 persons in plasma and urine matrices. It was possible to define percentiles of interest (P50 and P95) for almost all the TEs. Differences in TEs distribution between men and women were noticed in both matrices; age was also a cofactor.
CONCLUSIONS
This first Swiss biomonitoring of a large TEs-panel offers reference values in plasma and in urine for the Swiss population. The results obtained in this study were generally in line with clinical recommendations and comparable to levels reported in other population-based surveys.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Vogt, Bruno |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1434-6621 |
Publisher: |
Walter de Gruyter |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Apr 2024 08:14 |
Last Modified: |
22 Apr 2024 08:14 |
Publisher DOI: |
10.1515/cclm-2023-1433 |
PubMed ID: |
38641868 |
Uncontrolled Keywords: |
human biomonitoring inductively coupled plasma mass spectrometry (ICP-MS) plasma reference values trace elements urine |
URI: |
https://boris.unibe.ch/id/eprint/196132 |
Actions (login required)
 |
Edit item |