Oosterloo, Mayke; Touze, Alexiane; Byrne, Lauren M; Achenbach, Jannis; Aksoy, Hande; Coleman, Annabelle; Lammert, Dawn; Nance, Martha; Nopoulos, Peggy; Reilmann, Ralf; Saft, Carsten; Santini, Helen; Squitieri, Ferdinando; Tabrizi, Sarah; Burgunder, Jean-Marc; Quarrell, Oliver (2024). Clinical Review of Juvenile Huntington's Disease. (In Press). Journal of Huntington's disease IOS Press 10.3233/JHD-231523
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Juvenile Huntington's disease (JHD) is rare. In the first decade of life speech difficulties, rigidity, and dystonia are common clinical motor symptoms, whereas onset in the second decade motor symptoms may sometimes resemble adult-onset Huntington's disease (AOHD). Cognitive decline is mostly detected by declining school performances. Behavioral symptoms in general do not differ from AOHD but may be confused with autism spectrum disorder or attention deficit hyperactivity disorder and lead to misdiagnosis and/or diagnostic delay. JHD specific features are epilepsy, ataxia, spasticity, pain, itching, and possibly liver steatosis. Disease progression of JHD is faster compared to AOHD and the disease duration is shorter, particularly in case of higher CAG repeat lengths. The diagnosis is based on clinical judgement in combination with a positive family history and/or DNA analysis after careful consideration. Repeat length in JHD is usually > 55 and caused by anticipation, usually via paternal transmission. There are no pharmacological and multidisciplinary guidelines for JHD treatment. Future perspectives for earlier diagnosis are better diagnostic markers such as qualitative MRI and neurofilament light in serum.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Burgunder, Jean-Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1879-6400 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Apr 2024 12:33 |
Last Modified: |
01 May 2024 15:34 |
Publisher DOI: |
10.3233/JHD-231523 |
PubMed ID: |
38669553 |
BORIS DOI: |
10.48350/196291 |
URI: |
https://boris.unibe.ch/id/eprint/196291 |
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