Jay, Paul; Jeffries, Daniel; Hartmann, Fanny E; Véber, Amandine; Giraud, Tatiana (2024). Why do sex chromosomes progressively lose recombination? Trends in genetics, 40(7), pp. 564-579. Elsevier Current Trends 10.1016/j.tig.2024.03.005
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Progressive recombination loss is a common feature of sex chromosomes. Yet, the evolutionary drivers of this phenomenon remain a mystery. For decades, differences in trait optima between sexes (sexual antagonism) have been the favoured hypothesis, but convincing evidence is lacking. Recent years have seen a surge of alternative hypotheses to explain progressive extensions and maintenance of recombination suppression: neutral accumulation of sequence divergence, selection of nonrecombining fragments with fewer deleterious mutations than average, sheltering of recessive deleterious mutations by linkage to heterozygous alleles, early evolution of dosage compensation, and constraints on recombination restoration. Here, we explain these recent hypotheses and dissect their assumptions, mechanisms, and predictions. We also review empirical studies that have brought support to the various hypotheses.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Evolutionary Ecology 08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) |
UniBE Contributor: |
Jeffries, Daniel Lee |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0168-9525 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Apr 2024 13:02 |
Last Modified: |
11 Jul 2024 00:14 |
Publisher DOI: |
10.1016/j.tig.2024.03.005 |
PubMed ID: |
38677904 |
Uncontrolled Keywords: |
evolutionary strata inversion mating-type chromosomes recombination suppression sex chromosomes supergenes |
BORIS DOI: |
10.48350/196322 |
URI: |
https://boris.unibe.ch/id/eprint/196322 |
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